Clone:
REAL962
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
NFM, NF-M, 160 kDa neurofilament protein, NEF3, Neurofilament 3, Neurofilament medium polypeptide, Neurofilament triplet M protein

Specifications for Neurofilament M (160 kD) Antibody, anti-human/mouse, REAdye_lease™

Overview

Clone REAL962 is an antibody fragment derived from the full Neurofilament M (160 kD) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL962 recognizes the human and mouse Neurofilament M (160 kD) protein, also known as Neurofilament 3 and belongs to the intermediate filament (IF) family. Neurofilaments IFs are components of most eukaryotic cells, differ significantly from other cellular cytoskeletal elements and are found predominantly in cells or tissues of neuronal origin. Mutations of the Neurofilament 160 KDa gene leads to neuroaxonal damages and further to various neurological disorders.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

NFM, NF-M, 160 kDa neurofilament protein, NEF3, Neurofilament 3, Neurofilament medium polypeptide, Neurofilament triplet M protein

Detailed product information

Technical specifications

CloneREAL962
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenNeurofilament M (160 kD)
Alternative names of antigenNFM, NF-M, 160 kDa neurofilament protein, NEF3, Neurofilament 3, Neurofilament medium polypeptide, Neurofilament triplet M protein
Distribution of antigenneural cells, tumor cells

Resources for Neurofilament M (160 kD) Antibody, anti-human/mouse, REAdye_lease™

Certificates

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References for Neurofilament M (160 kD) Antibody, anti-human/mouse, REAdye_lease™

Publications

  1. Greenwood, J. A. et al. (1093) Phosphorylation modulates calpain-mediated proteolysis and calmodulin binding of the 200-kDa and 160-kDa neurofilament proteins. J Neurochem 61(1): 191-199
  2. Khalil, M. et al. (2018) Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol. 14(10): 577-589

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