Clone:
REA1019
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Klra3, Klra6, Klra8, Klra9

Specifications for Ly-49C/F/I/H Antibody, anti-mouse, REAfinity™

Overview

Clone REA1019 recognizes a common epitope of the mouse Ly-49C/F/I/H family members which are single-pass type II C-type lectin-like membrane glycoproteins also known as Ly-49 inhibitory receptors C, F, and I and activating receptor H. It does not react with other Ly-49 members. The Ly-49 receptors are encoded by a family of highly polymorphic and polygenic genes within the mouse NK gene complex which includes genes that encode both inhibitory and activating Ly-49 receptors. Ly-49 receptors recognize MHC-I and MHC-I–like proteins on normal as well as altered cells. They are described as being expressed on both the developing and mature NK cells. The inhibitory Ly-49 receptors are involved in NK cell education, a process in which NK cells acquire function and tolerance toward cells that express “self-MHC-I.” On the other hand, the activating Ly-49 receptors recognize altered cells expressing activating ligands. Ly-49 receptors have been described on multiple NK cell subsets, such as uterine NK and memory NK cells, as well as NKT cells, dendritic cells, plasmacytoid dendritic cells, macrophages, neutrophils, and cells of the adaptive immune system such as activated T cells and regulatory CD8
+
T cells.
Additional information: Clone REA1019 displays negligible binding to Fc receptors.

Alternative names

Klra3, Klra6, Klra8, Klra9

Detailed product information

Technical specifications

CloneREA1019
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-49C/F/I/H
Alternative names of antigenKlra3, Klra6, Klra8, Klra9
Molecular mass of antigen [kDa]31(average of subunits)
Distribution of antigendendritic cells, macrophages, NK cells, CD8+ T cells, neutrophils, NKT cells, plasmacytoid dendritic cells
Entrez Gene ID16634, 16637, 16640, 16639
RRIDAB_2727846, AB_2727847, AB_2727848, AB_2727831

Resources for Ly-49C/F/I/H Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for Ly-49C/F/I/H Antibody, anti-mouse, REAfinity™

Publications

  1. Wong, S. et al. (1991) Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains. J. Immunol. 147(4): 1417-1423
  2. Rahim, M. M. et al. (2014) Ly49 receptors: innate and adaptive immune paradigms. Front Immunol 5: 145-145
  3. Tu, M. M. et al. (2014) Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells. Cancer Res. 74(14): 3684-3694

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