Clone:
REA1214
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TGFB1, CED, DPD1

Specifications for LAP (TGF-β1) Antibody, anti-human, REAfinity™

Overview

Clone REA1214 recognizes the N-terminal latency-associated peptide (LAP) of the transforming growth factor β1 (TGF-β1) dimer. TGF-β1 belongs to a family of homologous, disulfide-linked, homodimeric proteins. These highly pleiotropic cytokines inhibit proliferation of most cells, but can promote the growth of mesenchymal cells and enhance extracellular matrix formation. The pivotal function of TGF-β1 in the immune system is to mediate immunosuppression and maintain tolerance by regulating lymphocyte proliferation, differentiation, and survival. TGF-β1 is produced by many cell types, but is reported to be most abundant in mammalian platelets and bone. It is secreted predominantly as an inactive latent complex. After proteolytical processing of the TGF-β1 precursor, the resulting N-terminal latency-associated peptide (LAP) remains non-covalently associated with the TGF-β1 dimer. Mature and biologically active TGF-β1 can be released from the complex by action of proteases and/or conformational changes. LAP-TGF-β1 was described to be expressed on the cell surface of activated human regulatory T cells.
Additional information: Clone REA1214 displays negligible binding to Fc receptors.

Alternative names

TGFB1, CED, DPD1

Detailed product information

Technical specifications

CloneREA1214
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenLAP (TGF-β1)
Alternative names of antigenTGFB1, CED, DPD1
Molecular mass of antigen [kDa]28
Distribution of antigenplatelets, bone
Entrez Gene ID7040
RRIDAB_2876987, AB_2876922, AB_2876923, AB_2876986

Resources for LAP (TGF-β1) Antibody, anti-human, REAfinity™

Certificates

Please follow this
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References for LAP (TGF-β1) Antibody, anti-human, REAfinity™

Publications

  1. Tran, D.Q. et al. (2009)
    Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FoxP3
    +
    regulatory T cells allows for their purification from expansion cultures.
    Blood 113: 5125-5133
  2. Tran, D. Q. et al. (2009)
    GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3
    +
    regulatory T cells.
    Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450

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