Clone:
REA516
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B

Specifications for IRF-8 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA516 recognizes the human and mouse interferon regulatory factor 8 (IRF-8) antigen, a 50 kDa transcription factor, which is also known as interferon consensus sequence–binding protein (ICSBP). IRF-8 belongs to the family of interferon regulatory transcription factors, which consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain with a unique tryptophan pentad repeat. IRF-8 is expressed at very high levels in mononuclear phagocytes, and regulates granulocyte/macrophage differentiation and dendritic cell (DC) development. Acting in heterodimeric complexes with other transcription factors, IRF-8 also controls the transcriptional response of mature myeloid cells to interferons and Toll-like receptor agonists, a response in which IRF-8 binds and transactivates the promotors of IL12B and NOS2. IRF-8 knockout mice display a loss of CD8a
+
lymphoid DCs, CD103
+
tissue myeloid DCs, and plasmacytoid DCs.
Additional information: Clone REA516 displays negligible binding to Fc receptors.

Alternative names

IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B

Detailed product information

Technical specifications

CloneREA516
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenIRF-8
Alternative names of antigenIRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B
Molecular mass of antigen [kDa]48(same molecular weight for human and mouse/rat)
Distribution of antigendendritic cells, granulocytes, macrophages, monocytes
Entrez Gene ID3394, 15900
RRIDAB_2857568, AB_2857570

Resources for IRF-8 Antibody, anti-human/mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for IRF-8 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Hambleton, S. et al. (2011) IRF8 mutations and human dendritic-cell immunodeficiency. N. Engl. J. Med. 365(2): 127-138
  2. Yoshida, Y. et al. (2014) The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity 40(2): 187-198
  3. Driggers, P. H. et al. (1990) An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. U.S.A. 87(10): 3743-3747

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