Clone:
REA1008
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IL10, CSIF, Interleukin-10

Specifications for IL-10 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1008 recognizes the interleukin-10 (IL-10) cytokine, which is predominantly secreted by CD4
+
T cells and antigen-presenting cells, such as monocytes/macrophages and dendritic cells. IL-10 has important suppressive functions on immune responses and is believed to be involved in the maintenance of tolerance. IL-10 blocks activation of cytokine synthesis by Tʜ1 cells, activated monocytes, and NK cells. It can stimulate immunoglobulin production by B cells.
Additional information: Clone REA1008 displays negligible binding to Fc receptors.

Alternative names

IL10, CSIF, Interleukin-10

Detailed product information

Technical specifications

CloneREA1008
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-10
Alternative names of antigenIL10, CSIF, Interleukin-10
Molecular mass of antigen [kDa]19
Distribution of antigendendritic cells, macrophages, monocytes, antigen-presenting cells, CD4+ T cells
Entrez Gene ID16153
RRIDAB_2727718, AB_2727791, AB_2727719, AB_2727792, AB_2727720, AB_2727793, AB_2727721, AB_2727790

Resources for IL-10 Antibody, anti-mouse, REAfinity™

Certificates

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References for IL-10 Antibody, anti-mouse, REAfinity™

Publications

  1. Ajuebor, M. N. et al. (1999) Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation. Biochem. Biophys. Res. Commun. 255(2): 279-282
  2. Assaman, C. et al. (1999) An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190(7): 995-1004

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