Clone:
REA176
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HLA-B, AS, SPDA1

Specifications for HLA-B7, B27 Antibody, anti-human, REAfinity™

Overview

Clone REA176 recognizes HLA B7 and B27 class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. HLA-B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. HLA-B27 is known for its strong association with inflammatory spondyloarthropathies. It has been also discovered as a protective factor against some severe viral infections.
Additional information: Clone REA176 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Detailed product information

Technical specifications

CloneREA176
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-B7, B27
Alternative names of antigenHLA-B, AS, SPDA1
Molecular mass of antigen [kDa]38
Distribution of antigenother
Entrez Gene ID3106
RRIDAB_2733749, AB_2752059, AB_2752046, AB_2811539, AB_2811531, AB_2652117, AB_2652118, AB_2733748

Resources for HLA-B7, B27 Antibody, anti-human, REAfinity™

Certificates

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References for HLA-B7, B27 Antibody, anti-human, REAfinity™

Publications

  1. Akram, A. et al. (2014) HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent. J. Immunol. 192(12): 5520-5528
  2. Akram, A. et al. (2013) Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection. Eur. J. Immunol. 43(12): 3254-3267
  3. den Uyl, D. et al. (2004) Progression of HIV to AIDS: a protective role for HLA-B27? AIDS Rev. 6(2): 89-96

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