Clone:
REA407
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
PTK2, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FADK 1

Specifications for FAK pS910 Antibody, anti-human, REAfinity™

Overview

Clone REA407 recognizes the human focal adhesion kinase (FAK) antigen phosphorylated at serine 910 (pS910). FAK is a 125 kDa non-receptor and non-membrane cytoplasmic tyrosine kinase that plays critical roles in integrin-mediated signal transductions and also participates in signaling by other cell surface receptors. In integrin-mediated cell adhesion, FAK is activated via disruption of an auto-inhibitory intra-molecular interaction between its amino terminal FERM domain and the central kinase domain. The activated FAK forms a complex with Src family kinases, which initiates multiple downstream signaling pathways through phosphorylation of other proteins to regulate different cellular functions. Those signaling pathways are identified to mediate FAK regulation of migration of various normal and cancer cells. Serine 910 (pS910) is a prominent site differentially phosphorylated in response to neurotransmitters, bioactive lipids, tumor promoters, and growth factors in intestinal epithelial cells.
Additional information: Clone REA407 displays negligible binding to Fc receptors.

Alternative names

PTK2, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FADK 1

Detailed product information

Technical specifications

CloneREA407
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenFAK pS910
Alternative names of antigenPTK2, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FADK 1
Molecular mass of antigen [kDa]119
Entrez Gene ID5747
RRIDAB_2651716, AB_2651717

Resources for FAK pS910 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for FAK pS910 Antibody, anti-human, REAfinity™

Publications

  1. Jiang, X. et al. (2007) Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell. Signal. 19(5): 1000-1010
  2. Zhao, X. et al. (2011) Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv. Drug Deliv. Rev. 63(8): 610-615
  3. Whitney, G. S. et al. (1993) Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. DNA Cell Biol. 12(9): 823-830

Related products for
FAK pS910 Antibody, anti-human, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?