Clone:
REA565
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IHC, IF
Alternative names:
ICF, MmuIIIB, ICF1, M.HsaIIIB

Specifications for Dnmt3b Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA565 recognizes the Dnmt3b antigen, which is a DNA methyltransferase, that performs
de novo
DNA methylation during embryonic development. It may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation and may play a role in controlling the differentiation of human ES cells and in the generation of iPS cells. Dnmt3 is expressed ubiquitously, at higher levels expressed in mouse and human embryonic stem (ES), in fetal liver, heart, kidney, and placenta.
Additional information: Clone RE565 displays negligible binding to Fc receptors.

Alternative names

ICF, MmuIIIB, ICF1, M.HsaIIIB

Detailed product information

Technical specifications

CloneREA565
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
AntigenDnmt3b
Alternative names of antigenICF, MmuIIIB, ICF1, M.HsaIIIB
Molecular mass of antigen [kDa]96, 97(separately shown for human and mouse/rat)
Distribution of antigenother
Entrez Gene ID1789, 444985
RRIDAB_2651578, AB_2651579, AB_2651580

Resources for Dnmt3b Antibody, anti-human/mouse/rat, REAfinity™

Certificates

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References for Dnmt3b Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Yajun, L. et al. (2010) Interaction between DNMT3B and polycomb repression complexes and their role in histone modification. Cancer Res. 70: 4868-4868
  2. Wongtrakoongate, P. et al. (2014) DNMT3B inhibits the re-expression of genes associated with induced pluripotency. Exp. Cell Res. 321(2): 231-239
  3. Niederwieser, C. et al. (2015) Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia. Leukemia 29(3): 567-575
  4. Torroglosa, A. et al. (2014) Involvement of DNMT3B in the pathogenesis of Hirschsprung disease and its possible role as a regulator of neurogenesis in the human enteric nervous system. Genet. Med. 16(9): 703-710

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