CytoStim has been developed for rapid and efficient restimulation of non-human primate effector/memory T cells.

Specifications for CytoStim™, non-human primate

Overview

CytoStim has been developed for rapid and efficient restimulation of non-human primate effector/memory T cells.

Detailed product information

Background information

CytoStim causes activation of T cells by binding to the T cell receptor (TCR) and cross-linking it to a major histocompatibility complex molecule of an antigen–presenting cell. CytoStim is an antibody–based reagent that acts similarly to a superantigen but independently of certain Vβ domains of the TCR. Upon incubation with CytoStim, CD4
+
and CD8
+
cells start to secrete effector cytokines or up-regulate activation markers on their cell surface within a few hours. CytoStim is suitable for rapid stimulation of CD4
+
and CD8
+
T cells in fresh PBMCs, whole blood, or other leukocyte-containing single-cell suspensions from tissues. It can be used instead of SEB as a positive control in antigen-specific T cell stimulation assays or intracellular cytokine staining experiments to detect cytokine or activation marker expression.

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