CytoStim has been developed for rapid and efficient restimulation of human effector/memory T cells.

Specifications for CytoStim™, human

Overview

CytoStim has been developed for rapid and efficient restimulation of human effector/memory T cells.

Detailed product information

Background information

CytoStim is an antibody-based reagent that acts similarly to a superantigen but independently of certain Vβ domains of the T cell receptor (TCR). It causes activation of T cells by binding to the TCR and crosslinking it to an MHC molecule of an antigen-presenting cell. Upon stimulation with CytoStim, CD4
+
and CD8
+
T cells start to secrete cytokines or up-regulate activation markers on their cell surface within a few hours. CytoStim is suitable for rapid stimulation of CD4
+
and CD8
+
T cells in fresh peripheral blood mononuclear cells (PBMCs), whole blood, or other leukocyte-containing single-cell suspensions from tissues. It can be used instead of SEB as a positive control in antigen-specific T cell stimulation assays or intracellular cytokine staining experiments to detect cytokine or activation marker expression.

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