Clone:
REA544
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
INPE5792, KACL, PILAR, UNQ5792, CLEC-2A

Specifications for CLEC2A Antibody, anti-human, REAfinity™

Overview

Clone REA544 recognizes the human CLEC2A antigen, which is a member of the C-type lectin-like domain–containing family. It enhances TCR-stimulated T cell expansion by upregulating anti-apoptotic proteins and may modulate the capacity of T cells to home to lymph nodes through SELL. It facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. In contrast to the other CLEC2 family members AICL, CD69, and LLT1, CLEC2A is predominantly expressed in skin.
Additional information: Clone REA544 displays negligible binding to Fc receptors.

Alternative names

INPE5792, KACL, PILAR, UNQ5792, CLEC-2A

Detailed product information

Technical specifications

CloneREA544
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCLEC2A
Alternative names of antigenINPE5792, KACL, PILAR, UNQ5792, CLEC-2A
Molecular mass of antigen [kDa]20
Distribution of antigenNK cells, T cells
Entrez Gene ID387836
RRIDAB_2651422, AB_2651423, AB_2651424, AB_2651425, AB_2651426, AB_2651421

Resources for CLEC2A Antibody, anti-human, REAfinity™

Certificates

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References for CLEC2A Antibody, anti-human, REAfinity™

Publications

  1. Huarte, E. et al. (2008) PILAR is a novel modulator of human T-cell expansion. Blood 112(4): 1259-1268
  2. Spreu, J. et al. (2010) Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. U.S.A. 107(11): 5100-5105

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