Clone:
REAL271
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3, VEA

Specifications for CD69 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL271 is an antibody fragment derived from the full CD69 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL271 recognizes the human CD69 antigen, also known as activation inducer molecule (AIM). CD69 is involved in the early events of lymphocyte, monocyte, and platelet activation. Cross-linking of CD69 induces cytotoxic activity and costimulates cytokine production of activated NK cells and selected T cell clones. CD69 is transiently expressed on activated leukocytes including T cells, thymocytes, B cells, NK cells, neutrophils, and eosinophils. It is constitutively expressed by a subset of medullary mature thymocytes, platelets, mantle B cells, and certain CD4+ T cells in germinal centers of normal lymph nodes.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3, VEA

Detailed product information

Technical specifications

CloneREAL271
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD69
Alternative names of antigenAIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3, VEA
Distribution of antigenT cells, B cells, granulocytes, NK cells, other, eosinophils, neutrophils, thymocytes, regulatory T cells, Langerhans cells, tonsil

Resources for CD69 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD69 Antibody, anti-human, REAdye_lease™

Publications

  1. Hamann, J. et al. (1993) Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. J. Immunol. 150(11): 4920-4927
  2. López-Cabrera, M. et al. (1993) Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. J. Exp. Med. 178(2): 537-547
  3. Lin, G. X. et al. (2002) Cross-reactivity of CD antibodies in eight animal species. In: Leucocyte typing VII, Oxford University Press. : 519-524

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