Clone:
REA344
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
SELP, GMP-140, GRMP, LECAM3, PADGEM, P-selectin

Specifications for CD62P Antibody, anti-mouse, REAfinity™

Overview

Clone REA344 recognizes the mouse CD62P antigen, a 140 kDa single-pass type I membrane protein also known as P-selectin or platelet activation dependent granule-external membrane protein (PADGEM). CD62P is expressed by vascular endothelial cells and platelets. The protein is stored preformed in the Weibel-Palade bodies of endothelial cells and in the α-granules of platelets. Upon stimulation of these cells with a variety of agonists such as thrombin or histamine, P-selectin is rapidly translocated to the cell surface, where it mediates leukocyte-platelet and leukocyte-vascular endothelial cell adhesion. The interaction of P-selectin with mature leukocytes is in part responsible for mediating leukocyte rolling on vascular cells, an early event in leukocyte recruitment at sites of inflammation. In addition to its role as a receptor for mature neutrophils and monocytes, P-selectin also functions as a cell adhesion molecule for leukocyte precursor cells in the bone marrow, including both lineage-restricted clonogenic progenitors and hierarchically more primitive progenitor cells.
Additional information: Clone REA344 displays negligible binding to Fc receptors.

Alternative names

SELP, GMP-140, GRMP, LECAM3, PADGEM, P-selectin

Detailed product information

Technical specifications

CloneREA344
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD62P
Alternative names of antigenSELP, GMP-140, GRMP, LECAM3, PADGEM, P-selectin
Molecular mass of antigen [kDa]79
Distribution of antigenendothelial cells, platelets
Entrez Gene ID20344
RRIDAB_2658876, AB_2658877, AB_2658878, AB_2658879, AB_2658880, AB_2658881, AB_2658882, AB_2658883, AB_2811412

Resources for CD62P Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

Reviews for CD62P Antibody, anti-mouse, REAfinity™

P-Selectin On Cultured Mouse Skin Endothelial Cells

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CD62P-APC, mouse (130-105-537)

The aim is to detect P-selectin on cultured mouse skin endothelial cells using flow cytometry. This antibody works well.

References for CD62P Antibody, anti-mouse, REAfinity™

Publications

  1. Sanders, W. E. et al. (1992)
    Molecular cloning and analysis of
    in vivo
    expression of murine P-selectin.
    Blood 80(3): 795-800
  2. Xia, L. et al. (2003) N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. Blood 101(2): 552-559
  3. Weller, A. et al. (1992) Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha. J. Biol. Chem. 267(21): 15176-15183
  4. Ando, Y. et al. (2016) Platelet supernatant suppresses LPS-induced nitric oxide production from macrophages accompanied by inhibition of NF-κB signaling and increased arginase-1 expression. PLoS One 11: :e0162208

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