Clone:
REA505
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CD44s, CD44A, METAA, RHAMM, CD44, Pgp-1, H-CAM, CD44st, CD44std

Specifications for CD44H Antibody, anti-rat, REAfinity™

Overview

Clone REA505 recognizes the rat CD44H antigen, a transmembrane glycoprotein, also known as homing-associated cell adhesion molecule (H-CAM) or phagocytic glycoprotein-1 (Pgp-1). CD44H belongs to the CD44 group, that encompasses several isoforms expressed in a variety of tissues. It is highly expressed on hematopoietic and non-hematopoietic cells. All isoforms are encoded by the same gene on chromosome 11 and are formed by alternative splicing of their mRNA. CD44 isoforms belong to the family of cell adhesion molecules and to the sub-family of the hyaladherins in consideration of their affinity for hyaluronate and their structural homology with the cartilage link protein. The standard form of CD44, CD44H, exhibits a high affinity for hyaluronate, plays a role in the uptake and degradation of this glycosaminoglycan, and participates in cell locomotion in its presence.
Additional information: Clone REA505 displays negligible binding to Fc receptors.

Alternative names

CD44s, CD44A, METAA, RHAMM, CD44, Pgp-1, H-CAM, CD44st, CD44std

Detailed product information

Technical specifications

CloneREA505
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD44H
Alternative names of antigenCD44s, CD44A, METAA, RHAMM, CD44, Pgp-1, H-CAM, CD44st, CD44std
Molecular mass of antigen [kDa]54
Distribution of antigenstem cells, hematopoietic stem and progenitor cells
Entrez Gene ID25406
RRIDAB_2658193, AB_2658194, AB_2658195, AB_2658196, AB_2658197, AB_2658198, AB_2658199, AB_2658200, AB_2658201, AB_2658202, AB_2658203, AB_2658204, AB_2658205, AB_2658206, AB_2658192

Resources for CD44H Antibody, anti-rat, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD44H Antibody, anti-rat, REAfinity™

Publications

  1. Zheng, Z. et al. (1995) Monoclonal antibodies to CD44 and their influence on hyaluronan recognition. J. Cell Biol. 130(2): 485-495
  2. Thomas, L. (1993) CD44, the hyaluronic acid cell receptor. Its role in neoplastic invasion and metastatic dissemination. Bull Cancer 80(10): 833-844

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