Clone:
CX5
Type of antibody:
Primary antibodies
Isotype:
rat IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d

Specifications for CD314 (NKG2D) Antibody, anti-mouse

Overview

Clone CX5 recognizes mouse CD314 (NKG2D), a type II transmembrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family. CD314 in mice is expressed on activated CD8
+
αβ T cells, NK cells, subsets of γδ T cells, IFN-producing killer dendritic cells, subsets of NKT cells, and activated macrophages. For signaling, CD314 associates with signaling adapters DAP10 and DAP12 and transduces signal via the PI3-kinase pathway and the Syk-Zap70 pathways, respectively. CD314 recognizes multiple ligands, which are either uregulated in response to cellular stresses such as heat shock, infection, and DNA damage or are constitutively expressed, such as on tumor cells. Known ligands of CD314 in mice include murine UL16-binding protein-like transcript (MULTI), H60 family proteins and the five retinoic acid-inducible proteins RAE-1α, β, γ, δ, ε. Interaction of CD314 with its ligands regulates cytotoxic response towards the cells bearing the cognate ligands.

Alternative names

Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d

Detailed product information

Technical specifications

CloneCX5
Clonalitymonoclonal
Isotyperat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD314 (NKG2D)
Alternative names of antigenKlrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d
Molecular mass of antigen [kDa]27
Distribution of antigenT cells, NK cells, macrophages, dendritic cells, NKT cells
Entrez Gene ID27007
RRIDAB_2657376, AB_2657377, AB_2657378, AB_2657379, AB_2657380, AB_2657381, AB_2657382, AB_2657375

Resources for CD314 (NKG2D) Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD314 (NKG2D) Antibody, anti-mouse

Publications

  1. Takada, A. et al. (2008) Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J. Immunol. 180: 1678-1685
  2. McMahon, C. et al. (2002) The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17(1): 19-29
  3. Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1(2): 119-126
  4. Yokoyama, W. M. et al. (2002) NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3(12): 1150-1155

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