Clone:
REA1046
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
KDR, Flk1, VEGFR, VEGFR2

Specifications for CD309 (VEGFR-2) Antibody, anti-human, REAfinity™

Overview

Clone REA1046 recognizes the CD309 antigen, a transmembrane tyrosine kinase, also known as vascular endothelial growth factor receptor-2 (VEGFR-2) or kinase insert domain–containing receptor (KDR). CD309 is a high-affinity receptor for VEGF and plays a role in hematopoiesis. It is also involved in angiogenesis, both during embryogenesis and in the context of homeostatic or pathological events, e.g., vascularization of tumors. It has been identified on a subset of hematopoietic stem cells (HSCs), endothelial progenitor cells (EPCs), as well as on their common progenitor, the hemangioblast. CD309 expression is also found on mature endothelial cells (ECs).
Additional information: Clone REA1046 displays negligible binding to Fc receptors.

Alternative names

KDR, Flk1, VEGFR, VEGFR2

Detailed product information

Technical specifications

CloneREA1046
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD309 (VEGFR-2)
Alternative names of antigenKDR, Flk1, VEGFR, VEGFR2
Molecular mass of antigen [kDa]149
Distribution of antigenendothelial cells, megakaryocytes, platelets, hematopoietic stem and progenitor cells, pancreas, smooth muscle
Entrez Gene ID3791
RRIDAB_2733728, AB_2733729, AB_2733307, AB_2733308, AB_2732935, AB_2732936, AB_2733181, AB_2733182, AB_2733085, AB_2733086, AB_2733984, AB_2733985

Resources for CD309 (VEGFR-2) Antibody, anti-human, REAfinity™

Certificates

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References for CD309 (VEGFR-2) Antibody, anti-human, REAfinity™

Publications

  1. Flamme, I. et al. (1995) Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo. Dev. Biol. 169: 699-712
  2. Shalaby, F. et al. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66
  3. Auerbach, R. et al. (1996) Hematopoietic stem cells in the mouse embryonic yolk sac. Stem Cells 14: 269-280
  4. Eichmann, A. et al. (1997) Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic Proc. Natl. Acad. Sci. U.S.A. 94: 5141-5146

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