Clone:
REA224
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

Specifications for CD272 (BTLA) Antibody, anti-mouse, REAfinity™

Overview

Clone REA224 recognizes the mouse CD272 antigen, which is also known as B- and T-lymphocyte attenuator (BTLA) or B- and T-lymphocyte-associated protein. CD272, an Ig domain superfamily receptor protein with similarities to cytotoxic T-lymphocyte antigen-4 and programmed death-1, is expressed on various cell types like splenic T and B cells, macrophages, NK cells, dendritic cells as well as lymph node tissues but very weakly in somatic tissues. A polymorphic tissue distribution between several mouse strains is seen. Crosslinking CD272 with antigen receptors results in downregulation of T cell activation and attenuates production of interleukin 2. CD272 deficient mice have increased specific antibody responses and enhanced incidence and severity of autoimmune disorders.
Additional information: Clone REA224 displays negligible binding to Fc receptors.

Alternative names

BTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

Detailed product information

Technical specifications

CloneREA224
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD272 (BTLA)
Alternative names of antigenBTLA, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein
Molecular mass of antigen [kDa]31
Distribution of antigenB cells, NK cells, T cells
Entrez Gene ID208154
RRIDAB_2656857, AB_2656858, AB_2656859, AB_2656860, AB_2656861, AB_2656856

Resources for CD272 (BTLA) Antibody, anti-mouse, REAfinity™

Certificates

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References for CD272 (BTLA) Antibody, anti-mouse, REAfinity™

Publications

  1. Watanabe, N. et al. (2003) BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4(7): 670-679
  2. Kobayashi, Y. et al. (2013) B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. U.S.A. 110: 5121-5126
  3. Murphy, T. L. et al. (2010) Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM. Annu. Rev. Immunol. 28: 389-411

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