Clone:
DJR2-4
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
TNFRSF10B, DR5, KILLER, TRAIL-R2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9

Specifications for CD262 Antibody, anti-human

Overview

The DJR2-4 antibody binds to death receptor 5 (DR5), member 10B of the TNF receptor superfamily (TNFRSF10B), also known as CD262, TRAIL-R2/ TRAILR2, TRICK2, KILLER, and ZTNFR9. Binding of TNF-related apoptosis-inducing ligand (TRAIL, TNFSF10, TL2, APO2L, Apo-2L) to DR5 induces apoptosis via the intracellular adaptor molecule FADD/MORT. The DR5 receptor is broadly expressed on many tumors and normal tissues. DR5 expression is upregulated by interferon α, taxotere, and paclitaxel, making DR5
+
target cells more susceptible to NK cell mediated killing.

Alternative names

TNFRSF10B, DR5, KILLER, TRAIL-R2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9

Detailed product information

Technical specifications

CloneDJR2-4
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD262
Alternative names of antigenTNFRSF10B, DR5, KILLER, TRAIL-R2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Molecular mass of antigen [kDa]42
Distribution of antigenleukocytes, thymocytes, heart, liver, lung, ovary, pancreas, placenta, spleen
Entrez Gene ID8795
RRIDAB_2656744, AB_2656745, AB_2656743

Resources for CD262 Antibody, anti-human

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD262 Antibody, anti-human

Publications

  1. Sato, K. et al. (2005) TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse. J. Immunol. 174(7): 4025-4033
  2. Uno, K. et al. (2003) TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells. Blood 101(9): 3658-3667
  3. Walczak, H. et al. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 16(17): 5386-5397
  4. LaVallee, T. M. et al. (2003) 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63(2): 468-475
  5. Nimmanapalli, R. et al. (2001) Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels. Cancer Res. 62(2): 759-763
  6. Qiu, Y. et al. (2007) The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells. Cancer Res. 67(10): 4973-4980
  7. Cheent, K. and Khakoo, S. I. (2011) Natural killer cells and hepatitis C: action and reaction. Gut 60(2): 268-278
  8. MacFarlane, M. et al. (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 272(41): 25417-25420
  9. Gajate, C. and Mollinedo, F. (2005) Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem. 280(12): 11641-11647
  10. Shigeno, M. et al. (2003) Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation. Oncogene 22(11): 1653-1662
  11. Stolfi, C. et al. (2011) 2-methoxy-5-amino-N-hydroxybenzamide sensitizes colon cancer cells to TRAIL-induced apoptosis by regulating death receptor 5 and survivin expression. Mol. Cancer Ther. 10(10): 1969-1981

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