Clone:
REA244
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFSF14, HVEML, LIGHT, LTg, TR2

Specifications for CD258 (LIGHT) Antibody, anti-human, REAfinity™

Overview

Clone REA244 recognizes the CD258 antigen, a type II transmembrane protein, which is also known as tumor necrosis factor ligand superfamily member 14 (TNFSF14), herpes virus entry mediator ligand (HVEML), or LIGHT, the acronym for “homologous to lymphotoxins, inducible expression, competes with HSV glycoprotein D for HVEM, a receptor expressed on T lymphocytes”. CD258 is expressed by activated T cells, NK cells, monocytes, granulocytes, and immature dendritic cells. The ligands of CD258 are HVEM, lymphotoxin β receptor, and decoy receptor DcR3/TR6. CD258 has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. CD258 is also reported to prevent tumor necrosis factor alpha–mediated apoptosis in primary hepatocytes. Its blockade or targeted disruption can alleviate alloresponses, graft rejection, or graft-versus-host disease.
Additional information: Clone REA244 displays negligible binding to Fc receptors.

Alternative names

TNFSF14, HVEML, LIGHT, LTg, TR2

Detailed product information

Technical specifications

CloneREA244
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD258 (LIGHT)
Alternative names of antigenTNFSF14, HVEML, LIGHT, LTg, TR2
Molecular mass of antigen [kDa]26
Distribution of antigendendritic cells, granulocytes, monocytes, NK cells, T cells
Entrez Gene ID8740
RRIDAB_2656712, AB_2656713, AB_2656714, AB_2656715, AB_2656716, AB_2656717, AB_2656718, AB_2656719, AB_2656720, AB_2656711

Resources for CD258 (LIGHT) Antibody, anti-human, REAfinity™

Certificates

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References for CD258 (LIGHT) Antibody, anti-human, REAfinity™

Publications

  1. Morel, Y. et al. (2000) Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. J. Immunol. 165: 4397-4404
  2. Mauri, D. N. et al. (1998) LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 8(1): 21-30
  3. Heo, S-K. et al. (2006) LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM. J. Leukoc. Biol. 79: 330-338

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