Clone:
REA327
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
RHCE, RHD, Rh polypeptide 2 (RhPII), Rhesus D antigen, Blood group Rh(CE) polypeptide (RHCE)

Specifications for CD240DCE Antibody, anti-human, REAfinity™

Overview

Clone REA327 recognizes the human CD240DCE antigens, multi-pass membrane proteins which are also known as blood group Rhesus (DCE) polypeptides. The Rhesus (Rh) blood group system is the most clinically significant blood group system after ABO. At present, the Rh blood group system consists of 50 defined blood-group antigens, among which the antigens D, C, and E are the most important. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic CD240D (RhD) protein on the surface of erythrocytes. Besides its role in blood transfusion, the Rh blood group system – specifically, the CD240D antigen – is used to determine the risk of hemolytic disease of the newborn as prevention is the best approach to the management of this condition.
Additional information: Clone REA327 displays negligible binding to Fc receptors.

Alternative names

RHCE, RHD, Rh polypeptide 2 (RhPII), Rhesus D antigen, Blood group Rh(CE) polypeptide (RHCE)

Detailed product information

Technical specifications

CloneREA327
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD240DCE
Alternative names of antigenRHCE, RHD, Rh polypeptide 2 (RhPII), Rhesus D antigen, Blood group Rh(CE) polypeptide (RHCE)
Molecular mass of antigen [kDa]45
Distribution of antigenred blood cells
Entrez Gene ID6007, 6006
RRIDAB_2656586, AB_2656587, AB_2656590, AB_2656591, AB_2656592, AB_2656593

Resources for CD240DCE Antibody, anti-human, REAfinity™

Certificates

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References for CD240DCE Antibody, anti-human, REAfinity™

Publications

  1. Smythe, J. S. et al. (1996) Expression of RHD and RHCE gene products using retroviral transduction of K562 cells establishes the molecular basis of Rh blood group antigens. Blood 87(7): 2968-2973
  2. Wagner, F. F. et al. (2000) RHD gene deletion occurred in the Rhesus box. Blood 95(12): 3662-3668
  3. Wagner, F. F. et al. (2004) Review: the molecular basis of the Rh blood group phenotypes. Immunohematology 20(1): 23-36

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CD240DCE Antibody, anti-human, REAfinity™

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