Clone:
REA276
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BCAM, AU, LU, MSK19, Lutheran antigen, Lutheran blood group glycoprotein

Specifications for CD239 (BCAM) Antibody, anti-human, REAfinity™

Overview

Clone REA276 recognizes the CD239 antigen, a type I membrane glycoprotein also known as basal cell adhesion molecule (BCAM) or Lutheran blood group glycoprotein (LU), which are two alternatively spliced variants of a single immunoglobulin superfamily protein that differ in the length of their cytoplasmic tails. Mouse and human CD239 is highly conserved at the amino acid sequence level. CD239 has a wide tissue distribution and is closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. The expression of CD239 is higher in fetal versus adult tissues, and is upregulated following malignant transformation in some cell types. CD239 is the receptor for laminin alpha-5, an extracellular matrix protein involved in cell differentiation, adhesion, migration, and proliferation. It may plays a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease.
Additional information: Clone REA276 displays negligible binding to Fc receptors.

Alternative names

BCAM, AU, LU, MSK19, Lutheran antigen, Lutheran blood group glycoprotein

Detailed product information

Technical specifications

CloneREA276
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD239 (BCAM)
Alternative names of antigenBCAM, AU, LU, MSK19, Lutheran antigen, Lutheran blood group glycoprotein
Molecular mass of antigen [kDa]64
Distribution of antigenother
Entrez Gene ID4059
RRIDAB_2656518, AB_2656519, AB_2656522, AB_2656523, AB_2656524, AB_2656525, AB_2656526, AB_2656527

Resources for CD239 (BCAM) Antibody, anti-human, REAfinity™

Certificates

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References for CD239 (BCAM) Antibody, anti-human, REAfinity™

Publications

  1. Parsons, S. F. et al. (2001) Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity. Blood 97(1): 312-320
  2. Rahuel, C. et al. (1996) A unique gene encodes spliceoforms of the B-cell adhesion molecule cell surface glycoprotein of epithelial cancer and of the Lutheran blood group glycoprotein. Blood 88(5): 1865-1872
  3. Campbell, I. G. et al. (1994) Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Cancer Res. 54(22): 5761-5765

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