Clone:
LT2
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG2bκ, mouse IgG2b
Applications:
FC, MICS, IF, IHC, FA
Alternative names:
LFA-2, SRBC-R, T11, SRBC

Extended validation for CD2 Antibody, anti-human

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with LT2
RPA-2.10++
REA972++
S5.2++
Cells were incubated with an excess of purified unconjugated CD2 (LT2) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD2 Antibody, anti-human

Overview

The CD2 antibody recognizes the human CD2 antigen, a 50 kDa single-chain transmembrane glycoprotein also known as LFA-2 or receptor for sheep erythrocytes. CD2 belongs to the Ig superfamily and is involved in cell signaling and lymphocyte adhesion. The CD2 antibody reacts with 80–90% of peripheral blood lymphocytes and more than 95% of thymocytes. The antibody recognizes all T cells and a subset of natural killer (NK) cells.

Alternative names

LFA-2, SRBC-R, T11, SRBC

Detailed product information

Technical specifications

CloneLT2
Clonalitymonoclonal
Isotypemouse IgG2bκ, mouse IgG2b
Isotype controlIsotype Control Antibody, mouse IgG2b
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
,
chimpanzee (
Pan troglodytes
)
,
squirrel monkey (
Saimiri sciureus
)
AntigenCD2
Alternative names of antigenLFA-2, SRBC-R, T11, SRBC
Molecular mass of antigen [kDa]37
Distribution of antigenB cells, macrophages, mast cells, NK cells, T cells, lymphocytes, thymocytes
Entrez Gene ID914
RRIDAB_2811681, AB_2811680, AB_1036111, AB_2661235, AB_2661236, AB_2661237, AB_2661238, AB_2661239, AB_2661240, AB_2661243, AB_2661244, AB_2661245, AB_2811543, AB_2801987, AB_2801966, AB_2811575

References for CD2 Antibody, anti-human

Publications

  1. Ozwara, H. et al. (1997)
    Flow cytometric analysis on reactivity of human T lymphocyte-specific and cytokine-receptor-specific antibodies with peripheral blood mononuclear cells of chimpanzee (
    Pan troglodytes
    ), rhesus macaque (
    Macacca mulatta
    ) and squirrel monkey (
    Saimiri sciureus
    ).
    J. Med. Primatol. 26(3): 164-171

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