Clone:
REA685
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, EBI1, MIP-3 beta receptor, EBI-1

Specifications for CD197 (CCR7) Antibody, anti-mouse, REAfinity™

Overview

Clone REA685 recognizes the mouse CD197 (CCR7) antigen, a chemokine receptor for chemokines CCL19 and CCL21. CD197, like other chemokine receptors has seven transmembrane spanning domains and signals via G proteins. Expression of CD197 is found on semi-mature and mature dendritic cells (DCs), naive B and T cells, regulatory T (Treg) cells, a subpopulation of T cells called central memory T cells, and non-immune malignant cells. CD197 is involved in regulating homing of immune cells, immunity to pathogens, immune tolerance, development and function of Tregs, and manifestation of autoimmunity.
Additional information: Clone REA685 displays negligible binding to Fc receptors.

Alternative names

C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, EBI1, MIP-3 beta receptor, EBI-1

Detailed product information

Technical specifications

CloneREA685
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD197 (CCR7)
Alternative names of antigenC-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR-7, EBI1, MIP-3 beta receptor, EBI-1
Molecular mass of antigen [kDa]40
Distribution of antigenB cells, dendritic cells, T cells
Entrez Gene ID12775
RRIDAB_2751994, AB_2655967, AB_2655968

Resources for CD197 (CCR7) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD197 (CCR7) Antibody, anti-mouse, REAfinity™

Publications

  1. Ritter, U. et al. (2004) Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells. J. Leukoc. Biol. 76(2): 472-476
  2. Bjorkdahl, O. et al. (2003) Characterization of CC-chemokine receptor 7 expression on murine T cells in lymphoid tissues. Immunology 110(2): 170-179
  3. Forster, R. et al. (2008) CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 8(5): 362-371

Related products for
CD197 (CCR7) Antibody, anti-mouse, REAfinity™

1 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?