Clone:
4B12
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC
Alternative names:
CCR7, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI1, Ebi1h

Specifications for CD197 (CCR7) Antibody, anti-mouse

Overview

Clone 4B12 reacts with CD197 (CCR7), a chemokine receptor for chemokines CCL19 and CCL21. CD197, like other chemokine receptors, has seven-transmembrane spanning domains and signals via G proteins. Expression of CD197 is found on semi-mature and mature dendritic cells (DCs), naive B and T cells, regulatory T (Treg) cells, a subpopulation of T cells called central memory T cells, and non-immune malignant cells. CD197 is involved in regulating homing of immune cells, immunity to pathogens, immune tolerance, development and function of Tregs, and manifestation of autoimmunity.

Alternative names

CCR7, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI1, Ebi1h

Detailed product information

Technical specifications

Clone4B12
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD197 (CCR7)
Alternative names of antigenCCR7, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI1, Ebi1h
Molecular mass of antigen [kDa]40
Distribution of antigenT cells, B cells, dendritic cells
Entrez Gene ID12775
RRIDAB_2655983, AB_2655984

Resources for CD197 (CCR7) Antibody, anti-mouse

Certificates

Please follow this
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References for CD197 (CCR7) Antibody, anti-mouse

Publications

  1. Bjorkdahl, O. et al. (2003) Characterization of CC-chemokine receptor 7 expression on murine T cells in lymphoid tissues. Immunology 110(2): 170-179
  2. Forster, R. et al. (2008) CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 8(5): 362-371

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