Clone:
REA465
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
BST-1

Specifications for CD157 (BST-1) Antibody, anti-human, REAfinity™

Overview

Clone REA465 recognizes the human CD157 antigen, a glycosylphosphatidylinositol (GPI) linked protein, which is also known as bone marrow stromal antigen 1 (BST-1) or cyclic ADP-ribose hydrolase 2. CD157, a member of the CD38 gene family, is an NAD-metabolizing ectoenzyme and a signaling molecule, which synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, former a second messenger that elicits calcium release from intracellular stores. It is mainly expressed by cells of the myeloid lineage, bone marrow stroma, and vascular endothelium. CD157 is also expressed by ovarian cancer epithelium and by peritoneal mesothelial cells, where it is implicated in tumor dissemination. Further, it is endowed with receptor-like features observed in different cell types and transduces signals by interacting with transmembrane partner molecules, a strategy shared by other GPI-anchored molecules. CD157 is involved in neutrophil polarization, adhesion, and motility and controls transendothelial migration.
Additional information: Clone REA465 displays negligible binding to Fc receptors.

Alternative names

BST-1

Detailed product information

Technical specifications

CloneREA465
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD157 (BST-1)
Alternative names of antigenBST-1
Molecular mass of antigen [kDa]30
Distribution of antigenendothelial cells, granulocytes, stromal cells, macrophages, monocytes, bone marrow
Entrez Gene ID683
RRIDAB_2801705, AB_2655309, AB_2655310, AB_2655313, AB_2655314, AB_2655315, AB_2655316, AB_2655317, AB_2655318, AB_2655319, AB_2655320, AB_2801706

Resources for CD157 (BST-1) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
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References for CD157 (BST-1) Antibody, anti-human, REAfinity™

Publications

  1. Kaisho, T. et al. (1994) BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc. Natl. Acad. Sci. U.S.A. 91(12): 5325-5329
  2. Ishihara, K. et al. (2000)
    BST-1/CD157 regulates the humoral immune responses
    in vivo
    .
    Chem. Immunol. 75: 235-255
  3. Morone, S. et al. (2014) Binding of CD157 protein to fibronectin regulates cell adhesion and spreading. J. Biol. Chem. 289(22): 15588-15601

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