Clone:
REA225
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CDH5, 7B4, VE-Cad, VECD, VEcad, Vec

Specifications for CD144 (VE-Cadherin) Antibody, anti-mouse, REAfinity™

Overview

Clone REA225 recognizes mouse CD144, which is also known as cadherin 5 or vascular endothelial cadherin (VE-Cadherin). This calcium-dependent cell–cell adhesion glycoprotein is composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. CD144 is a strictly endothelial specific adhesion molecule located at junctions between endothelial cells and is of vital importance for the maintenance and control of endothelial cell contacts. Mechanisms that regulate VE-cadherin–mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. CD144 also regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions.
Additional information: Clone REA225 displays negligible binding to Fc receptors.

Alternative names

CDH5, 7B4, VE-Cad, VECD, VEcad, Vec

Detailed product information

Technical specifications

CloneREA225
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD144 (VE-Cadherin)
Alternative names of antigenCDH5, 7B4, VE-Cad, VECD, VEcad, Vec
Molecular mass of antigen [kDa]83
Distribution of antigenendothelial cells
Entrez Gene ID12562
RRIDAB_2655164, AB_2655165, AB_2655166, AB_2655167, AB_2655168, AB_2655169

Resources for CD144 (VE-Cadherin) Antibody, anti-mouse, REAfinity™

Certificates

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References for CD144 (VE-Cadherin) Antibody, anti-mouse, REAfinity™

Publications

  1. Vestweber, D. et al. (2008) VE-Cadherin: The major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler. Thromb. Vasc. Biol. 28: 223-232
  2. Lampugnani, M. G. et al. (1992) A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J. Cell Biol. 118: 1511
  3. Ali, J. et al. (1997) Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. MIcrocirculation 4(2): 267-277

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