Clone:
REA625
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
OX40L receptor, OX-40, TNFRSF4

Specifications for CD134 (OX40) Antibody, anti-mouse, REAfinity™

Overview

Clone REA625 recognizes the CD134 antigen, also known as OX40 receptor, a 50 kDa type I membrane glycoprotein of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. OX40 is a secondary costimulatory molecule, which is expressed after 24 to 72 hours following activation. It is expressed on activated mouse T cells and B cells. The OX40 receptor binds to the OX40 ligand (CD252) to provide a costimulatory signal which is independent of CD28.
Additional information: Clone REA625 displays negligible binding to Fc receptors.

Alternative names

OX40L receptor, OX-40, TNFRSF4

Detailed product information

Technical specifications

CloneREA625
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD134 (OX40)
Alternative names of antigenOX40L receptor, OX-40, TNFRSF4
Molecular mass of antigen [kDa]28
Distribution of antigenB cells, T cells
Entrez Gene ID22163
RRIDAB_2654942, AB_2654943, AB_2654944, AB_2654945, AB_2654946, AB_2654947, AB_2654941

Resources for CD134 (OX40) Antibody, anti-mouse, REAfinity™

Certificates

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References for CD134 (OX40) Antibody, anti-mouse, REAfinity™

Publications

  1. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
  2. Kjaergaard, J. et al. (2001) Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J. Immunol. 167: 6669-6677
  3. al-Shamkhani, A. et al. (1996) OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 26(8): 1695-1699
  4. Hong, G. U. et al. (2015) IgE and IgA produced by OX40-OX40L or CD40-CD40L interaction in B cells-mast cells re-activate FcεRI or FcαRI on mast cells in mouse allergic asthma. Eur. J. Pharmacol. 754: 199-210

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