Clone:
REA228
Type of antibody:
Recombinant antibodies, Primary antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TNFRSF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII, TNFR-II), p75, p80 TNF-alpha receptor

Specifications for CD120b (TNF-RII) Antibody, anti-mouse, REAfinity™

Overview

Clone REA228 recognizes the extracellular part of the membrane-bound and truncated soluble form of the mouse CD120b antigen, a 75 kD type I transmembrane protein, which is also known as Tumor Necrosis Factor Receptor Type II (TNF-RII). CD120b is a receptor with high affinity for the mouse cytokine TNF-α and with lower affinity for LT-α. It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Additional information: Clone REA228 displays negligible binding to Fc receptors.

Alternative names

TNFRSF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII, TNFR-II), p75, p80 TNF-alpha receptor

Detailed product information

Technical specifications

CloneREA228
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyRecombinant antibodies, Primary antibodies
Speciesmouse
AntigenCD120b (TNF-RII)
Alternative names of antigenTNFRSF1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII, TNFR-II), p75, p80 TNF-alpha receptor
Molecular mass of antigen [kDa]48
Distribution of antigenB cells, T cells, lymphocytes
Entrez Gene ID21938
RRIDAB_2654730, AB_2654731, AB_2654734, AB_2654735, AB_2654736, AB_2654737, AB_2654738, AB_2654739, AB_2654740, AB_2654741

Resources for CD120b (TNF-RII) Antibody, anti-mouse, REAfinity™

Certificates

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References for CD120b (TNF-RII) Antibody, anti-mouse, REAfinity™

Publications

  1. van Mierlo, G. J. et al. (2008) Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators J. Immunol. 180(5): 2747-2751
  2. Lewis, M. et al. (1991) Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific Proc. Natl. Acad. Sci. U.S.A. 88(7): 2830-2834
  3. Al-Lamki, R. S. et al. (2013)
    TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-Kit
    +
    cardiac stem cells in ischemic heart disease.
    Stem Cells 31(9): 1881-1892
  4. Siegmund, D. et al. (2016) Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis 7(9): e2375

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