Clone:
REA520
Type of antibody:
Recombinant antibodies, Primary antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF1B, TBPII, TNFR-II, TNF-R75, Tnfbr, TNFR1B, TNFR2, TNFR80, p75, p75TNFR

Specifications for CD120b (TNF-RII) Antibody, anti-human, REAfinity™

Overview

Clone REA520 recognizes the extracellular part of the membrane-bound form of the human CD120b antigen, a 75 kDa single-pass type I membrane protein, which is also known as tumor necrosis factor receptor type II (TNF-RII). CD120b is a receptor with high affinity for the cytokine tumor necrosis factor (TNF-α) and for lymphotoxin-alpha (LT-α). It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.
Additional information: Clone REA520 displays negligible binding to Fc receptors.

Alternative names

TNFRSF1B, TBPII, TNFR-II, TNF-R75, Tnfbr, TNFR1B, TNFR2, TNFR80, p75, p75TNFR

Detailed product information

Technical specifications

CloneREA520
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyRecombinant antibodies, Primary antibodies
Specieshuman
AntigenCD120b (TNF-RII)
Alternative names of antigenTNFRSF1B, TBPII, TNFR-II, TNF-R75, Tnfbr, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Molecular mass of antigen [kDa]46(refers to canonical form)
Distribution of antigenB cells, T cells, lymphocytes, monocytes, macrophages, granulocytes, dendritic cells, endothelial cells, leukocytes, myeloid leukemia cells, NK cells, thymocytes, hematopoietic stem and progenitor cells, T helper cells, NKT cells, cardiac muscle
Entrez Gene ID7133
RRIDAB_2751836

Resources for CD120b (TNF-RII) Antibody, anti-human, REAfinity™

Certificates

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References for CD120b (TNF-RII) Antibody, anti-human, REAfinity™

Publications

  1. Hostager, B. S. et al. (2002) Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b. J. Immunol. 168(7): 3318-3322
  2. Kohno, T. et al. (1990) A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor. Proc. Natl. Acad. Sci. U.S.A. 87(21): 8331-8335
  3. Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9(1): 38

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