Clone:
REA378
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, ICC, IHC, MC
Alternative names:
ITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 α chain

Specifications for CD11a Antibody, anti-human, REAfinity™

Overview

Clone REA378 recognizes the human CD11a antigen, a single-pass type I membrane protein also known as integrin α-L (ITGAL). Integrins are heterodimeric adhesion molecules comprised of α- and β-subunits that participate in immune cell interactions as well as in immune cell-extracellular matrix interactions. CD11a combines with CD18 (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 is a receptor for CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), and CD242 (ICAM-4). It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T cell–mediated killing, and antibody dependent killing by granulocytes and monocytes. Interactions between LFA-1 and CD54 (ICAM-1) play a critical role in T cell–B cell collaboration.
Additional information: Clone REA378 displays negligible binding to Fc receptors.

Alternative names

ITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 α chain

Detailed product information

Technical specifications

CloneREA378
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate, other
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
,
chimpanzee (
Pan troglodytes
)
,
olive baboon (
Papio anubis
)
, capuchin monkey, horse, cattle (bovine, cow), sheep, dog, rabbit
AntigenCD11a
Alternative names of antigenITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 α chain
Molecular mass of antigen [kDa]126
Distribution of antigenleukocytes, T cells, granulocytes, monocytes
Entrez Gene ID3683
RRIDAB_2783916, AB_2819706, AB_2819698, AB_2801921, AB_2654618, AB_2654619, AB_2654622, AB_2654623, AB_2654624, AB_2654625, AB_2654630, AB_2654631, AB_2783917

Resources for CD11a Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD11a Antibody, anti-human, REAfinity™

Publications

  1. Lowes, M. A. et al. (2005) Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc. Natl. Acad. Sci. U.S.A. 102(52): 19057-19062
  2. Larson, R. S. et al. (1989) Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. J. Cell Biol. 108(2): 703-712
  3. Zhou, Y. et al. (2012) Usefulness of CD11a and CD18 in flow cytometric immunophenotypic analysis for diagnosis of acute promyelocytic leukemia. Am. J. Clin. Pathol. 138(5): 744-750

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