Clone:
REAL635
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Calponin-1, Basic calponin, Calponin H1 smooth muscle, Calponin 1, CNN1

Specifications for Calponin Antibody, anti-human, REAdye_lease™

Overview

Clone REAL635 is an antibody fragment derived from the full Calponin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL635 recognizes the human Calponin, a filament-associated calcium binding protein also known as Calponin-1 or CNN1. Calponin is strongly expressed in osteoblasts and smooth muscle cells. It binds several actin binding proteins and phospholipids e.g. actin, calmodulin, troponin C and tropomyosin. Calponin plays a role in the actin-myosin interaction and inhibits the ATPase activity of myosin in smooth muscle tissue.
Calponin-1 belongs to cancer-releated genes and operates as a biomarker particulary as prognostic marker in tumor cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Calponin-1, Basic calponin, Calponin H1 smooth muscle, Calponin 1, CNN1

Detailed product information

Technical specifications

CloneREAL635
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCalponin
Alternative names of antigenCalponin-1, Basic calponin, Calponin H1 smooth muscle, Calponin 1, CNN1
Distribution of antigenosteoblasts, tumor cells, other, smooth muscle
RRIDAB_2857573

Resources for Calponin Antibody, anti-human, REAdye_lease™

Certificates

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References for Calponin Antibody, anti-human, REAdye_lease™

Publications

  1. Fujii, T. et al. (1995) Interaction of calponin with phospholipids. J. Biochem. 117(5): 999-1003
  2. Applegate, D. et al. (1994) Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle. J. Biol. Chem. 269(14): 10683-10690
  3. Sasaki, Y. et al. (2002) Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosis. Cancer 94(6): 1777-1786

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