Clone:
REA118
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
CBL, CBL2, FRA11B, NSLL, RNF55

Specifications for c-Cbl pY774 Antibody, anti-human, REAfinity™

Overview

Clone REA118 recognizes the Y774-phosphorylated form of human c-Cbl, which is a member of Cbl family of proteins. Cbl proteins serve as the negative regulators of antigen receptor signaling and contain N-terminal tyrosine kinase-binding (TKB) domain, which mediates binding to specific phosphotyrosine motifs on activated protein tyosine kinases (PTKs), a Zn-coordinating RING finger domain that interacts with ubiquitin-conjugating enzymes (E2s), a proline-rich region and a C-terminal leucine zipper-like region. c-Cbl unlike the other cbl proteins contains only a short proline-rich region and no C-terminal leucine zipper-like region. Cbl proteins acts as E3 ubiquitin ligase and tranfer ubiquitin molecules to tag activated receptors, PTKS, and signaling molecules for degradation.
Additional information: Clone REA118 displays negligible binding to Fc receptors.

Alternative names

CBL, CBL2, FRA11B, NSLL, RNF55

Detailed product information

Technical specifications

CloneREA118
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
Antigenc-Cbl pY774
Alternative names of antigenCBL, CBL2, FRA11B, NSLL, RNF55
Molecular mass of antigen [kDa]100
Entrez Gene ID867
RRIDAB_2651346, AB_2651347, AB_2651348, AB_2651349, AB_2651350, AB_2651351, AB_2651352, AB_2651345

Resources for c-Cbl pY774 Antibody, anti-human, REAfinity™

Certificates

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References for c-Cbl pY774 Antibody, anti-human, REAfinity™

Publications

  1. Joazeiro, C. A. P. et al. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309
  2. Rao, N. et al. (2002) The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J. Leukoc. Biol. 71: 753-763

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