Clone:
REAL641
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CTNNB1, CTNB1, Beta-catenin, Catnb

Specifications for β-Catenin Antibody, anti-human, REAdye_lease™

Overview

Clone REAL641 is an antibody fragment derived from the full β-Catenin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL641 recognizes the human β-Catenin antigen, a 92 kDa dual function protein regulating the coordination of cell-cell adhesion and gene transcription. β-Catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. As a component of adherens junctions, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CTNNB1, CTNB1, Beta-catenin, Catnb

Detailed product information

Technical specifications

CloneREAL641
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse
Antigenβ-Catenin
Alternative names of antigenCTNNB1, CTNB1, Beta-catenin, Catnb
Distribution of antigenendothelial cells, epithelial cells, keratinocytes, fibroblasts, other, ovarian cancer

Resources for β-Catenin Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for β-Catenin Antibody, anti-human, REAdye_lease™

Publications

  1. Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257(5073): 1142-1144
  2. Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149(6): 1192-1205
  3. Yu, W. et al. (2017) β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells. Cell. Physiol. Biochem. 44(2): 467-478
  4. MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17(1): 9-26
  5. Shang, S. et al. (2017) The regulation of β-catenin activity and function in cancer: therapeutic opportunities. Oncotarget. 8(20): 33972-33989

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