Clone:
REA480
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, IF, IHC, MICS
Alternative names:
CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb

Specifications for β-Catenin Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA480 recognizes the human and mouse β-catenin antigen, a 92 kDa dual function protein regulating the coordination of cell-cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. As a component of adherens junctions, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor adenomatous polyposis coli (APC). Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors as well as ovarian and endometrial cancer.
Additional information: Clone REA480 displays negligible binding to Fc receptors.

Alternative names

CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb

Detailed product information

Technical specifications

CloneREA480
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Antigenβ-Catenin
Alternative names of antigenCTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb
Molecular mass of antigen [kDa]85
Distribution of antigenendothelial cells, epithelial cells, fibroblasts, keratinocytes
Entrez Gene ID1499, 12387
RRIDAB_2784494, AB_2819500, AB_2819492, AB_2811667, AB_2811666, AB_2784495

Resources for β-Catenin Antibody, anti-human/mouse, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for β-Catenin Antibody, anti-human/mouse, REAfinity™

Publications

  1. Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257(5073): 1142-1144
  2. Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149(6): 1192-1205
  3. MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17(1): 9-26

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