Clone:
REA676
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
Protein kinase B, PKB

Specifications for AKT Pan (PKB) Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA676 recognizes the human, mouse, and rat AKT antigen. AKT is a family of serine/threonine kinases which is also known as protein kinase B (PKB) or related to the A and C kinases (RAC-PK). AKT intricately regulates many cellular functions such as cell growth and proliferation, cell survival, apoptosis, energy metabolism, and resistance to anti-cancer therapeutics. It consists of three isoforms, AKT1, AKT2, and AKT3 (or PKBα, β, and γ). Although these three isoforms are encoded by separate genes, they share a common NH2-terminal pleckstrin homology (PH) domain, a catalytic domain in the middle, and a COOH terminus. The identity of the overall amino acid sequence of the three isoforms is very high (about 80%); however, the COOH terminus and the PH-linker region are more diverse. All three isoforms contain similar phosphorylation/activation sites: threonine 308 (AKT1), 309 (Akt2), and 305 (AKT3) and serine 473 (Akt1), 474 (AKT2), and 472 (AKT3). Phosphorylated or activated AKT regulates many of its cellular functions through the phosphorylation of a series of downstream players.
Additional information: Clone REA676 displays negligible binding to Fc receptors.

Alternative names

Protein kinase B, PKB

Detailed product information

Technical specifications

CloneREA676
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
AntigenAKT Pan (PKB)
Alternative names of antigenProtein kinase B, PKB
Molecular mass of antigen [kDa]56(same molecular weight for human and mouse/rat)
Distribution of antigenubiquitous
Entrez Gene ID11651, 24185, 207
RRIDAB_2651207, AB_2651208, AB_2857837, AB_2857840

Resources for AKT Pan (PKB) Antibody, anti-human/mouse/rat, REAfinity™

Certificates

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References for AKT Pan (PKB) Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Calamito, M. et al. (2010) Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 115: 4043-4050
  2. Arranz, A. et al. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc. Natl. Acad. Sci. U.S.A. 109(24): 9517-9522
  3. Santi, S. A. et al. (2010) The Akt isoforms are present at distinct sub cellular locations. Am. J. Physiol., Cell Physiol. 298(3): 580-591

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