CliniMACS® Plus Instrument

Automated cell separation for clinical-scale cell enrichment or depletion

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The user-friendly key components of the CliniMACS® Plus Instrument offer sophisticated applications for a whole variety of separations. The selected stem cells, monocytes, DCs, NK cells, B cells, and T cell subsets allow research in the field of regenerative medicine, adoptive immunotherapy, and graft engineering.

Cells are magnetically labeled in the Cell Preparation Bag using an antigen-specific reagent. Subsequently, the Cell Preparation Bag is connected to the CliniMACS Plus Instrument. Intuitive software facilitates target cell enrichment or depletion as well as final collection in the Cell Collection Bag. The CliniMACS System separates large numbers of cells providing target cells with high purity and excellent yield. A range of tubing sets optimized for different applications is available.

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Benefits Features & specifications Applications Support

Benefits

Versatile

Variety of cell separation strategies available – for high purity and excellent yield

Certified medical device

Functionally closed system, compatible for use in a GMP setting

Well-established technology

Tried and tested for more than 20 years

Easy to use

Automated cell separation for reproducible processes

Features & specifications

Touchscreen

Software guides the operator through interactions

Magnet unit

Houses the separation column for enrichment or depletion of magnetically labeled cells

Peristaltic pump

Directs accurate volumes of liquids through the tubing set

Pinch valves

Ensure controlled fluid pathways within the tubing set

Bag hangers

Hold buffer and starting material during cell processing

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Touchscreen

Software guides the operator through interactions

Magnet unit

Houses the separation column for enrichment or depletion of magnetically labeled cells

Peristaltic pump

Directs accurate volumes of liquids through the tubing set

Pinch valves

Ensure controlled fluid pathways within the tubing set

Bag hangers

Hold buffer and starting material during cell processing

The CliniMACS CD34 Reagent System

The CliniMACS CD34 Reagent System is a medical device that enables in vitro enrichment of CD34-positive hematopoietic stem cells for graft-versus-host disease (GVHD) prophylaxis in patients with AML. Watch the video to learn more.

CliniMACS Plus Instrument specifications

Dimensions	70 cm × 60 cm × 90–140 cm (w × d × h)
Weight	approx. 35 kg
Input voltage	100–240 V~
Power consumption	350 W
Frequency	50/60 Hz
Types of starting material	Leukapheresis, bone marrow
Available processing steps	Cell depletion and / or enrichment via magnetic cell separation
Monitor	10.1” TFT touchscreen
Tubing Sets	Dedicated CliniMACS Tubing Sets available
Manufacture and availability	Manufactured in Germany and shipped worldwide

Applications

A wide variety of automated cell separation applications are supported by the CliniMACS Plus System. If your workflow of interest is not highlighted below, please visit our clinical application page.

Support

Technical and field service support

Comprehensive service options ensure maximum performance of the CliniMACS Plus Instruments over time.

We provide the necessary official documentation for installation and operational qualifications required to maintain GMP standards.