UltraMicroscope Blaze™

Automated light sheet imaging of large samples

The UltraMicroscope Blaze is the only fully automated light sheet microscope for imaging large or multiple cleared samples at subcellular resolution. Our pioneering UltraMicroscope technology combined with cutting-edge light sheet optics ensures excellent data quality. 

A standard sample chamber allows convenient imaging of multiple rodent organs or organoids. Additionally, the new XXL chamber represents a powerful upgrade, specially designed to provide the largest possible sample space for the UltraMicroscope Blaze. It enables fitting of samples as big as a human kidney or whole adult mouse models.
 

Benefits

Full automation

The UltraMicroscope Blaze enables an automated sample release and smooth switching between different objectives and magnification lenses, while keeping images sharp with the autofocus feature. 

Large sample chambers  

A standard sample chamber allows convenient imaging of multiple rodent organs or organoids, and the new XXL chamber provides the largest possible sample space for the UltraMicroscope Blaze.

Easy adaptation 

Whether imaging large organs or even entire mouse models, our wide range of dipping caps guarantees high image quality in all clearing media - from water to organic solvents.

High-resolution 

The combination of the MI Plan objective lenses and the cutting-edge light sheet illumination technology ensures unprecedented image quality from overview to sub-cellular details.

 

Features and specifications 

UltraMicroscope UM Blaze

MI Plan objectives

MI Plan objectives (1.1×, 4×, and 12×) are optimized for high-resolution 3D imaging of large samples in any clearing media.

Automated chamber

Imaging of multiple specimens without user intervention and easy sample exchange by automated sample release.

Automated detection unit

Fully automated switching of all lenses combined with the autofocus feature ensure a convenient imaging process.

Cutting-edge light sheet optics

Up to six light sheets make for improved optical sectioning and homogeneous illumination.

1 2 3 4

MI Plan objectives

MI Plan objectives (1.1×, 4×, and 12×) are optimized for high-resolution 3D imaging of large samples in any clearing media.

Automated
chamber

Imaging of multiple specimens without user intervention and easy sample exchange by automated sample release.

Automated detection unit

Fully automated switching of all lenses combined with the autofocus feature ensure a convenient imaging process.

Cutting-edge light sheet optics

Up to six light sheets make for improved optical sectioning and homogeneous illumination.

UltraMicroscope UM Blaze
  • Vigouroux, R. J. et al. (2021) Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods. Science 372(6538): 150-156
  • Pan, C. et al. (2019) Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body. Cell 179(7): 1661-1676
  • Zhao, S. et al. (2020) Tridimensional Visualization and Analysis of Early Human Development. Cell 180(4): 796-812
  • Taranda, J. et al. (2021) 3D Whole-Brain Imaging Approaches to Study Brain Tumors. Cancers (Basel) 13(8): 1897
  • Gregorius, J. et al. (2021) Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Basic Res Cardiol 116(1): 40
  • Michel, L. et al. (2021) Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy. Eur Heart J. 43(4): 316-329
 

Applications

The UltraMicroscope Blaze allows us to see every single cancer metastasis in the whole bodies of transparent mice and we can also see if drugs are targeting all those tiny micro-metastases. The UltraMicroscope Blaze will be a powerful tool for drug development in oncology. 
Dr. Ali Ertürk
Director of iTERM, Helmholtz Zentrum München, Germany
 

Support

Service where you need it

 

UltraMicroscope Blaze

Automated light sheet imaging of largest samples

Order no. 150-001-760

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