TLR3 agonists

Effective activation of immune cells with TLR3 agonists

  • Synthetic single-stranded RNAs (ORNs)
  • Potent and specific immune cell stimulation in human and mouse
  • Easy handling, with buffers included
TLR3 is a member of the Toll-like receptor (TLR) family recognizing pathogen-associated molecular patterns (PAMPS). TLR3 recognizes virally-derived, double- or single-stranded RNA leading to activation of immune cells such as dendritic cells and B cells. The natural ligands for TLR3 can be mimicked by synthetic RNA oligoribonucleotides (ORNs) like polyinosinic-polycytidylic acid or Poly (I:C), which hybridize to form RNA double strands in aqueous solutions with high ionic strength.

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