Find the products and resources you are looking for!
Miltenyi Biotec distribution:
As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is committed to providing our customers around the world with the highest quality products. In addition to direct selling in more than 20 countries in North America, Europe and Asia/Pacific, Miltenyi Biotec also provides support for our customers through an extensive distributor network covering dozens of additional countries.
Chimeric antigen receptor (CAR) T cells are a promising new alternative for the treatment of B cell malignancies and other cancer types to eliminate tumor cells in diseased patients1,2. This hope is based upon results from studies where CAR T cell treatments have found to be effective in relapsed lymphoblastic leukemia, multiple myeloma and lymphoma.
The success of these studies have generated a significant interest in CAR T cells. However, manual CAR T cell manufacturing is complex and labor intensive and extensive training of personnel is required to avoid operator variations3. Conventional protocols comprise many open handling steps and are difficult to upscale for increasing numbers of patients. Therefore, automation plays an increasingly important role and provides process standardization for consistent results.
The CliniMACS Prodigy® simplifies the manufacturing processes and enables the automated production of CAR T cells4,5. The instrument is able to perform cell enrichment, activation, genetic manipulation, and expansion with minimal involvement from the user. All steps take place in a closed system, providing a sterile solution for the challenges associated with clinical-grade CAR T cell production. All reagents for cell enrichment and activation as well as cytokines and media are available in MACS® GMP quality.
The advantages of the CliniMACS Prodigy for the clinical-scale production of CAR T cells:
1. Anurathapan, U. et al. (2014) Cyotherapy 16: 713–733
2. Maus, M. V. et al. (2014) Blood 123: 2625–2635
3. Mock, U. et al. (2016) Cytotherapy 18: 1002–1011
4. Blaeschke, F. et al. (2018) Cancer Immunology, Immunotherapy 67: 1053–1066
5. Lock, D. et al. (2017) Human Gene Therapy 28: 914–925
Copyright © 2020 Miltenyi Biotec and/or its affiliates. All rights reserved.