Clone:
15E8
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG1
Applications:
FC, MICS, IF, IHC, ICC, FA
Alternative names:
Tp44, T44

Specifications for CD28 Antibody, anti-human

Overview

The CD28 antibody recognizes the human CD28 antigen, a type I transmembrane protein, which is highly expressed on CD3
+
thymocytes, most peripheral thymocytes and plasma cells. Binding of CD28 to its ligands CD80 or CD86 costimulates T cell effector function and T cell–dependent antibody production
in vitro
and
in vivo
. In the presence of antibodies directed against CD2 and CD3, CD28 antibodies stimulate T cell proliferation and cytokine production.

Alternative names

Tp44, T44

Detailed product information

Technical specifications

Clone15E8
Clonalitymonoclonal
Isotypemouse IgG1
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigenCD28
Alternative names of antigenTp44, T44
Molecular mass of antigen [kDa]23
Distribution of antigenB cells, T cells, lymphocytes, plasma cells, thymocytes
Entrez Gene ID940
RRIDAB_2801822, AB_2752216, AB_2752213, AB_1036134, AB_1036117, AB_2660267, AB_2660268, AB_2660271, AB_871655, AB_2801826

References for CD28 Antibody, anti-human

Publications

  1. Kozbor D. J. et al. (1987) Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J. Immunol. 138(12): 4128-4132
  2. Bahlis, N. J. et al. (2007) CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood 109(11): 5002-5010
  3. Lécureuil et al. (2007) Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients. Blood 109: 3649-3657
  4. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
  5. Freeman, G. J. et al. (1993) Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262(5135): 909-911
  6. Linsley, P. S. et al. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212
  7. June, C. H. et al. (1990) Role of the CD28 receptor in T-cell activation. Immunol. Today 11(6): 211-216

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