Clone:
REA585
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TCR Vb8.1, 8.2, TCR Vbeta8.1, 8.2

Specifications for TCR Vβ8.1, 8.2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA585 recognizes the mouse Vβ8.1, 8.2 T cell receptor (TCR Vβ8.1, 8.2) but not Vβ8.3. Vβ8.1 and 8.2 are variants of the TCR β chain that associates with the TCR α chain. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains. TCR Vβ8.1, 8.2 is expressed on approximately 20 % of peripheral T cells in thymus, spleen, and other lymphoid organs in different mice strains, such as Balb/c, AKR, C57BL/6, AKR/B10.A.
Additional information: Clone REA585 displays negligible binding to Fc receptors

Alternative names

TCR Vb8.1, 8.2, TCR Vbeta8.1, 8.2

Detailed product information

Technical specifications

CloneREA585
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTCR Vβ8.1, 8.2
Alternative names of antigenTCR Vb8.1, 8.2, TCR Vbeta8.1, 8.2
Molecular mass of antigen [kDa]13
Distribution of antigenT cells, spleen
Entrez Gene ID100124677, 100124675
RRIDAB_2653913, AB_2653914, AB_2653915, AB_2653916, AB_2653917, AB_2653918, AB_2653919, AB_2653920, AB_2653923, AB_2653924, AB_2857778

References for TCR Vβ8.1, 8.2 Antibody, anti-mouse, REAfinity™

Publications

  1. Haskins, K. et al. (1984) The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J. Exp. Med. 160(2): 452-471
  2. Kuchroo, V. K. et al. (1994) T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. J. Exp. Med. 179(5): 1659-1664
  3. Mami-Chouaib, F. et al. (2002) Antitumor cytotoxic T-lymphocyte response in human lung carcinoma: identification of a tumor-associated antigen. Immunol. Rev. 188: 114-121

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