Clone:
REA681
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Tyrosine-protein kinase SYK

Specifications for Syk pY348 Antibody, anti-human, REAfinity™

Overview

Clone REA681 recognizes Syk protein phosphorylated at tyrosine 348. Syk is a 72 kDa non–receptor tyrosine kinase cytoplasmic protein. Syk belongs to the SYK/ZAP 70 family of tyrosine protein kinases and is mainly expressed in hematopoietic cells. Activated immunoreceptors, phosphorylated at ITAM motifs recruit Syk from the cytoplasm to the signalosome complex at the perimembrane location. Syk, upon binding of SH2 domains to immunoreceptor ITAM is activated and undergoes autophosphorylation and phosphorylation by SRC kinases. Activated Syk catalyzes tyrosine phosphorylation of multiple downstream proteins which regulate signaling pathways such AKT, MAP kinase, and NF-κB. A wide variety of cellular and physiological functions such as cell activation and differentiation are regulated by Syk. Phosphorylation at Tyr-348 creates a binding site for VAV1.
Additional information: Clone REA681 displays negligible binding to Fc receptors.

Alternative names

Tyrosine-protein kinase SYK

Detailed product information

Technical specifications

CloneREA681
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse
AntigenSyk pY348
Alternative names of antigenTyrosine-protein kinase SYK
Molecular mass of antigen [kDa]72
Distribution of antigenB cells, T cells, breast cancer cells
Entrez Gene ID6850
RRIDAB_2653633, AB_2653634, AB_2653635, AB_2653632

Resources for Syk pY348 Antibody, anti-human, REAfinity™

Certificates

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References for Syk pY348 Antibody, anti-human, REAfinity™

Publications

  1. Kurosaki, T. et al. (1995) Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182(6): 1815-1823
  2. Sada, K. et al. (2001) Structure and function of Syk protein-tyrosine kinase. J. Biochem. 130: 177-186
  3. Siraganian, R. P. et al. Protein tyrosine kinase Syk in mast cell signaling. Mol. Immunol. 38(16-18): 1229-1233

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