Clone:
REA210
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IL-4 Stat, STAT6B, STAT6C

Specifications for STAT6 Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA210 recognizes the human signal transducer and activator of transcription 6 (STAT6) antigen, regardless of phosphorylation status. STAT proteins transmit signals from a receptor complex to the nucleus and activate gene expression. The seven members of the STAT family are predominantly activated by growth factors and cytokines. STAT6 expression is found in many human tissues. It is activated by two cytokines, interleukin 4 (IL-4) and IL-13, and plays a predominant role in the immune system. Once these cytokines bind to their cognate receptors, the associated Janus Kinases (Jak) are activated and phosphorylate conserved tyrosine residues on the receptor. Once phosphorylated, STAT6 forms homodimers and translocates to the nucleus. In the nucleus, STAT6 has the ability to bind directly to DNA via a DNA-binding domain and is able to regulate transcription. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites, as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis.
Additional information: Clone REA210 displays negligible binding to Fc receptors.

Alternative names

IL-4 Stat, STAT6B, STAT6C

Detailed product information

Technical specifications

CloneREA210
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivitycow
AntigenSTAT6
Alternative names of antigenIL-4 Stat, STAT6B, STAT6C
Molecular mass of antigen [kDa]94
Distribution of antigenT cells
Entrez Gene ID6778
RRIDAB_2653587, AB_2653588, AB_2653589, AB_2653590, AB_2653591, AB_2653586

Resources for STAT6 Antibody, anti-human/mouse/rat, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for STAT6 Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Hou, J. et al. (1994) An interleukin-4-induced transcription factor: IL-4 Stat. Science 265(5179): 1701-1706
  2. Leek, J. P. et al. (1997)
    Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by
    in situ
    hybridization.
    Cytogenet. Cell Genet. 79(3-4): 208-209

Related products for
STAT6 Antibody, anti-human/mouse/rat, REAfinity™

4 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?