Clone:
REA542
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
PLXND1, PLEXD1

Specifications for Plexin-D1 Antibody, anti-human, REAfinity™

Overview

Clone REA542 recognizes the human plexin-D1 antigen, a type I transmembrane glycoprotein that is a member of the D subfamily of semaphorin receptors. Plexin-D1 is amongst others the receptor for semaphorin 3E (Sema3E) which is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 plays an important role in cell-cell signaling and in regulating the migration of a wide spectrum of cell types, and is able to trigger R-Ras inactivation, leading to axonal and cell repulsion
in vitro.
Moreover, it was shown that Sema3E mediates either axonal attraction or repulsion in distinct neuronal populations, depending on the coexpression of neuropilin-1 with plexin-D1. Plexin-D1 expression is generally low in normal adult tissues, it is elevated in endothelial cells of tumor vessels and in cancer cells.
Additional information: Clone REA542 displays negligible binding to Fc receptors.

Alternative names

PLXND1, PLEXD1

Detailed product information

Technical specifications

CloneREA542
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenPlexin-D1
Alternative names of antigenPLXND1, PLEXD1
Molecular mass of antigen [kDa]208
Distribution of antigenendothelial cells
Entrez Gene ID23129
RRIDAB_2653249, AB_2653250, AB_2653253, AB_2653254, AB_2653255, AB_2653256

Resources for Plexin-D1 Antibody, anti-human, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for Plexin-D1 Antibody, anti-human, REAfinity™

Publications

  1. Casazza, A. et al. (2010) Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J. Clin. Invest. 120(8): 2684-2698
  2. Tamagnone, L. et al. (1999) Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell 99(1): 71-80
  3. Sakurai, A. et al. (2010) Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol. Cell. Biol. 30(12): 3086-3098

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