Clone:
REA374
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC

Specifications for Phosphotyrosine Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA374 recognizes phosphorylated tyrosine residues (p-Tyr) on proteins. Phosphorylation of proteins is an important regulatory mechanism that occurs in numerous intracellular signaling cascades. Within a protein, phosphorylation usually occurs on serine, threonine, tyrosine, and histidine residues. Phosphorylation on serine is the most common, followed by threonine. Tyrosine phosphorylation is relatively rare but is at the origin of protein phosphorylation signaling pathways in most of the eukaryotes.
Additional information: Clone REA374 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA374
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivitydog, rat, chicken, frog
AntigenPhosphotyrosine
Distribution of antigenother
RRIDAB_2653184, AB_2653185, AB_2653186, AB_2653187, AB_2653188, AB_2653189, AB_2653190, AB_2653183

Resources for Phosphotyrosine Antibody, anti-human/mouse, REAfinity™

Certificates

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References for Phosphotyrosine Antibody, anti-human/mouse, REAfinity™

Publications

  1. Takagi, S. et al. (1991) Intracellular localization of tyrosine kinase substrates beneath crosslinked surface immunoglobulins in B cells. J. Exp. Med. 174(2): 381-388
  2. Lund-Johansen, F. et al. (2000) Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions. Cytometry 39(4): 250-259
  3. Zentilin, L. et al. (2010) Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J. 24(5): 1467-1478

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