Clone:
REA924
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
MCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1

Specifications for Mcl-1 pS159 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA924 recognizes the human and mouse protein Mcl-1 phosphorylated at serine 159 (pS159). Myeloid cell leukemia-1 (Mcl-1), also known as BCL2L3, is a member of the Bcl-2 family of regulator proteins, which play an important role in the regulation of apoptosis. The two isoforms of Mcl-1 regulate cell survival and apoptosis by inhibiting apoptosis and promotion of apoptosis and death-inducing. Mcl-1 is primarily found in the outer membrane of mitochondria and mainly expressed in programmed myeloid cell differentiation.
Additional information: Clone REA924 displays negligible binding to Fc receptors.

Alternative names

MCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1

Detailed product information

Technical specifications

CloneREA924
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenMcl-1 pS159
Alternative names of antigenMCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1
Molecular mass of antigen [kDa]37, 35(separately shown for human and mouse/rat)
Distribution of antigenmyeloid leukemia cells
Entrez Gene ID4170, 17210
RRIDAB_2727036, AB_2727040, AB_2727037, AB_2727041, AB_2727038, AB_2727039

References for Mcl-1 pS159 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Kozopas, K. M. et al. (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. U.S.A. 90(8): 3516-3520
  2. Chao, J. R. et al. (1998) mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol. Cell. Biol. 18(8): 4883-4898
  3. Bingle, C. D. et al. (2000) Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J. Biol. Chem. 275(29): 22136-22146
  4. Maurer, U. et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21(6): 749-760

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