Clone:
REA160
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
LAT1, pp36, p36-38

Specifications for LAT pY171 Antibody, anti-human, REAfinity™

Overview

Clone REA160 recognizes the human linker for activation of T cell family member 1 (LAT) antigen phosphorylated at tyrosine 171 (pY171). LAT is an integral membrane protein that was initially detected as a major PTK substrate during T cell–receptor (TCR) activation. It is also involved in low affinity immunoglobulin gamma Fc region receptor III mediated signaling in natural killer cells and high affinity immunoglobulin epsilon receptor mediated signaling in mast cells. TCR-mediated LAT phosphorylation is critical for the membrane recruitment of signaling complexes required for T cell–activation. The LAT protein contains a short extracellular domain, a transmembrane sequence, and an extended cytoplasmic domain with nine tyrosine residues conserved in the mouse and human sequences. Some of these tyrosine residues have been shown to be docking sites for mediators of TCR signaling. Tyrosine 171 is suggested to be involved in more than merely creating SH2-binding sites and may affect the native conformation, localization, stability, and/or sequential phosphorylation of LAT during TCR stimulation.
Additional information: Clone REA160 displays negligible binding to Fc receptors.

Alternative names

LAT1, pp36, p36-38

Detailed product information

Technical specifications

CloneREA160
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenLAT pY171
Alternative names of antigenLAT1, pp36, p36-38
Molecular mass of antigen [kDa]28
Distribution of antigenT cells, NK cells, mast cells
Entrez Gene ID27040
RRIDAB_2652593, AB_2652594, AB_2652595, AB_2652592

Resources for LAT pY171 Antibody, anti-human, REAfinity™

Certificates

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References for LAT pY171 Antibody, anti-human, REAfinity™

Publications

  1. Larghi, P. et al. (2013) VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nat. Immunol. 14(7): 723-731
  2. Paz, P. E. et al. (2001) Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Biochem. J. 356(Pt 2): 461-471
  3. Zhang, W. et al. (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92(1): 83-92

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