Clone:
C8.6
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
mouse IgG1, mouse IgG1κ
Applications:
FA, ICFC
Alternative names:
IL12B, CLMF, CLMF2, Il-12b, IMD28, IMD29, NKSF, NKSF2

Specifications for IL-12 (p40/p70) Antibody, anti-human

Overview

Interleukin 12 (IL-12) is a 70–75 kDa heterodimeric cytokine composed of a 40 kDa heavy chain and a 35 kDa light chain. It is produced mainly by monocytes and macrophages as well as dendritic cells, primarily in response to stimulation with bacterial or viral antigens. IL-12 has also been described to be produced by non-hematopoietic cells such as keratinocytes and epidermoid carcinomas. IL-12 displays various effects on both T and NK cells, playing an essential role in the interaction between innate and adaptive immunity, for example, it induces the production of IFN-γ alone or in synergy with IL-2, is a co-stimulator of both NK and T cell proliferation, and enhances cytolytic activity of both cell types. Moreover, IL-12 promotes the development of T helper 1 (Tʜ1)-specific immune responses by promoting the differentiation of CD4
+
cells towards a Tʜ1 phenotype while inhibiting the production of Tʜ2 cells.
Clone C8.6 reacts with both, the p40 chain and the p70 heterodimer of human, rhesus monkey, and cynomolgus monkey IL-12.

Alternative names

IL12B, CLMF, CLMF2, Il-12b, IMD28, IMD29, NKSF, NKSF2

Detailed product information

Technical specifications

CloneC8.6
Clonalitymonoclonal
Isotypemouse IgG1, mouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies, Functional-grade antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigenIL-12 (p40/p70)
Alternative names of antigenIL12B, CLMF, CLMF2, Il-12b, IMD28, IMD29, NKSF, NKSF2
Molecular mass of antigen [kDa]35
Entrez Gene ID3593
RRIDAB_10829623, AB_2660583, AB_871564, AB_2660584, AB_871563

Resources for IL-12 (p40/p70) Antibody, anti-human

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for IL-12 (p40/p70) Antibody, anti-human

Publications

  1. D´Andrea, A. et al. (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176: 1387-1398
  2. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146

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