Human IL-35 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human IL-35

Overview

Human IL-35 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-35 can be used for a variety of applications including:
  • Induction of regulatory T cells.
  • Regulation of tumor growth.

Detailed product information

Background information

Human interleukin 35 (IL-35) consists of the IL-12 subunit alpha and the IL-27 subunit beta which is also known as EBI3. It plays a role in immune suppression and is produced by regulatory T cells and macrophages. IL-35 suppresses effector T cell proliferation, inhibits Th17 cell development, and promotes the conversion of T cells and B cells into regulatory T and B cells. Additionally, it is involved in regulation of tumor growth, autoimmune disease, and infectious tolerance.

Biological activity

  • Inhibition of proliferative activity of PBMCs.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
Premium-grade
cytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (macstec@miltenyibiotec.de).

Resources for Human IL-35

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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