Clone:
REA145
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HLA-B, AS, SPDA1

Specifications for HLA Class I B8 Antibody, anti-human, REAfinity™

Overview

Clone REA145 recognizes HLA B8, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA145 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Detailed product information

Technical specifications

CloneREA145
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA Class I B8
Alternative names of antigenHLA-B, AS, SPDA1
Molecular mass of antigen [kDa]38
Distribution of antigenendothelial cells, B cells, granulocytes, T cells, dendritic cells, macrophages
Entrez Gene ID3106
RRIDAB_2733668, AB_2733858, AB_2733859, AB_2652001, AB_2652002, AB_2652003, AB_2652004, AB_2652005, AB_2652006, AB_2652007, AB_2652008, AB_2733667

Resources for HLA Class I B8 Antibody, anti-human, REAfinity™

Certificates

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References for HLA Class I B8 Antibody, anti-human, REAfinity™

Publications

  1. Jahnsen, F. L. et al. (2018) Transcriptional and functional profiling defines human small intestinal macrophage subsets. J. Exp. Med. 215(2): 441-458
  2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
  3. Edvardsen, K. et al. (2016) Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison's disease. J. Transl. Med. 14: 68

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